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Peng Sun, PhD

Postdoctoral Researcher at Stanford Medicine studying auditory and vestibular function through zebrafish behavioral assays, molecular genetics, calcium imaging, and quantitative engineering platforms.

About

Academic background and current research focus.

Education

2016–2021

PhD · Electrical and Computer Engineering

University of Macau – Southern University of Science and Technology Joint PhD Program

Thesis: Behavioral assays for evaluating hearing and balance function in zebrafish larvae

Work Experience

2021.10 –

Postdoctoral Research Fellow

Stanford University

For a deeper understanding of the mechanisms of hearing and balance, I am currently exploring the role of the mechano-electrical transduction (MET) complex — particularly Tmc1/2 — in inner ear hair cells. My approach combines behavioral assays to quantify auditory and vestibular function, calcium imaging to visualize activity along auditory pathways in the intact brain, and RNA-FISH to examine the spatial expression patterns of Tmc genes in hair cells.

2015–2016

Research Assistant

Southern University of Science and Technology

Design behavioral assays and equipment for evaluating hearing and balance functions in zebrafish larvae.

Research

Integrating experimental biology and engineering to study sensory function at behavioral, cellular, and circuit levels.

I develop and apply integrated experimental platforms combining zebrafish behavioral assays, molecular genetics, and calcium imaging to investigate neural activity and uncover circuit mechanisms underlying auditory and vestibular function. Current work explores the role of Tmc1/2 proteins in inner ear hair cells and multisensory integration in the zebrafish brain.

This work bridges optical engineering, electronic and computer engineering, biomedical engineering, neuroscience, and quantitative analysis to enable precise characterization of sensory systems.

Zebrafish Behavior Auditory Neuroscience Vestibular Function Calcium Imaging Molecular Genetics Tmc1/2 Tmie Otogelin Hair Cells Optical Engineering Biomedical Engineering GPIAS / Startle Assay VOR Measurement Multisensory Integration

Selected Projects

Representative platforms and computational tools for studying sensory function in zebrafish.

VOR setup / eye-tracking result

Quantitative VOR Measurement System

High-precision platform for measuring vestibulo-ocular reflex in larval zebrafish using synchronized visual stimulation, imaging, and quantitative eye tracking. Patent: 201810321528.7

Acoustic stimulation / behavior tracking

Acoustic Startle & GPIAS Platform

Integrated behavioral system for studying auditory processing through acoustic startle response and gap-prepulse inhibition (GPIAS) assays in zebrafish larvae.

3D tracking / reconstruction figure

3D Eye Tracking & Reconstruction

Computational pipeline for reconstructing three-dimensional zebrafish eye movement dynamics and analyzing sensory-motor transformations with high spatial precision.

Publications

Peer-reviewed research in zebrafish sensory neuroscience and instrumentation.

13Peer-reviewed publications
5First or co-first author papers
5Patents
AROTravel award & multiple oral presentations
1
Anna Shipman, Yan Gao, Desheng Liu, Shan Sun, Jingjing Zang, Peng Sun et al. Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish vps4a mutants. Journal of Neuroscience 2024. 44(50).
2
Eliot Smith†, Peng Sun†, Shengyang Kevin Yu, David Raible and Teresa Nicolson. Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish. Frontiers in Molecular Neuroscience, 2023, 16: 1274822. (Co-first author)
3
Peng Sun, Eliot Smith, and Teresa Nicolson. Transmembrane channel-like (Tmc) subunits contribute to frequency sensitivity in the zebrafish utricle. Journal of Neuroscience, 2024, 44(1).
4
Xiaojie Yang†, Peng Sun†, Jian-Ping Wu, et al. Nondestructive and objective assessment of the vestibular function in rodent models: A review. Neuroscience Letters, 2020, 717: 134608. (Co-first author)
5
Peng Sun, Yingla Zhang, Feng Zhao, et al. An Assay for Systematically Quantifying the Vestibulo-Ocular Reflex to Assess Vestibular Function in Zebrafish Larvae. Frontiers in Cellular Neuroscience, 2018, 12.
6
Shanshan Han, Xiliang Liu, Shanglun Xie, Meng Gao, Fei Liu, Shanshan Yu, Peng Sun et al. Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy. Human Genetics, 2018, 137(10): 779–794.
7
Qin Yang, Peng Sun, Shi Chen, Hongzhe Li and Fangyi Chen. Behavioral methods for the functional assessment of hair cells in zebrafish. Frontiers of Medicine, 2017: 1–13.
8
Changquan Wang, Zhenmin Zhong, Peng Sun, et al. Evaluation of the Hair Cell Regeneration in Zebrafish Larvae by Measuring and Quantifying the Startle Responses. Neural Plasticity, 2017.
9
Peng Sun, Liyun Zhong, Chunshu Luo, Wenhu Niu and Xiaoxu Lu. Visual measurement of the evaporation process of a sessile droplet by dual-channel simultaneous phase-shifting interferometry. Scientific Reports, 2015, 5.
10
Chunshu Luo, Liyun Zhong, Peng Sun, Hanling Wang, Jindong Tian, and Xiaoxu Lu. Two-Step Demodulation Algorithm Based on the Orthogonal of Diamond Diagonal Vectors. Applied Physics B, 119 (2015), 387–91.
11
Wenhu Niu, Liyun Zhong, Peng Sun, Xiaoxu Lu. Phase shifts extraction algorithm based on Gram–Schmidt orthonormalization of two vectors. Optical and Quantum Electronics, 2015, 1–8.
12
Wenhu Niu, Liyun Zhong, Peng Sun, Wangping Zhang and Xiaoxu Lu. Two-step phase retrieval algorithm based on the quotient of inner products of phase-shifting interferograms. Journal of Optics, 2015, 17(8): 085703.

Conferences

Selected presentations at international meetings.

2025
48th ARO MidWinter Meeting · Orlando, FL · Podium presentation: "Multisensory Integration in the Zebrafish Brain: Hearing Loss Affects the Bimodal Audio–Visual Interactions in the Tectum"
2024
47th ARO MidWinter Meeting · Anaheim, CA
2023
46th ARO MidWinter Meeting · Orlando, FL · Podium presentation: "The C-Terminus of MET Component Tmie Contributes to High Frequency Sensitivity of the Vestibular System" · ARO Travel Award
2020
43rd ARO MidWinter Meeting · San Jose, CA
2019
14th International Zebrafish Conference · Suzhou, China

Get in Touch

I welcome conversations about zebrafish behavioral systems, auditory and vestibular neuroscience, quantitative imaging, and collaborative engineering platforms for sensory biology.